Polynucleotides are the next generation of regenerative injectables, celebrated for their ability to revitalise skin from within rather than simply filling or tightening it. Often referred to as biostimulators, they contain highly purified, sterilised fish DNA fragments \u2014 most commonly derived from salmon or trout \u2014 which work at a cellular level to repair, regenerate and protect the skin.<\/p>\n
Once injected, these DNA molecules signal fibroblast activity, stimulating the natural production of collagen, elastin and hyaluronic acid. The result is smoother, firmer, more luminous skin that looks naturally refreshed \u2014 without added volume or drastic change. Polynucleotides also have anti-inflammatory and antioxidant properties, helping to restore skin health, improve texture, and calm signs of stress or damage.<\/p>\n
At Dr Preema London Clinic in Mayfair, Polynucleotides are used within personalised treatment plans to strengthen and renew the skin\u2019s foundation, supporting long-term rejuvenation and overall skin vitality.<\/p>\n
<\/span><\/p>\n <\/span><\/p>\n [\/et_pb_text][\/et_pb_column][et_pb_column type=”1_2″ _builder_version=”4.14.2″ _module_preset=”default” global_colors_info=”{}”][et_pb_image src=”https:\/\/drpreema.com\/wp-content\/uploads\/2025\/04\/polynucleotides-skin-repair-treatment-men-dr-preema-london.jpg.webp” alt=”Polynucleotide injection being performed at Dr Preema London Clinic to support collagen synthesis and skin healing in men.” title_text=”Polynucleotides for Skin Repair \u2013 Dr Preema Clinic” _builder_version=”4.14.2″ _module_preset=”default” width=”80%” module_alignment=”center” border_radii=”off|20px||20px|” global_colors_info=”{}”][\/et_pb_image][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_2,1_2″ _builder_version=”4.14.2″ _module_preset=”default” global_colors_info=”{}” custom_padding=”3px|||||”][et_pb_column type=”1_2″ _builder_version=”4.14.2″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.14.2″ text_font=”||||||||” text_line_height=”2em” header_font=”||||||||” header_line_height=”0em” header_3_font=”Prata||||||||” header_3_font_size=”20px” header_3_line_height=”1.6em” custom_margin=”||||false|false” custom_padding=”||0px|||” link_option_url=”#” locked=”off” global_colors_info=”{}” text_text_color__hover=”#ff7a6b” header_3_text_color__hover=”#ff7a6b” header_4_font_size__hover=”18px” header_4_font_size__hover_enabled=”18px” header_4_letter_spacing__hover=”0px” header_4_letter_spacing__hover_enabled=”0px” header_4_line_height__hover=”1em” header_4_line_height__hover_enabled=”1em” header_4_text_shadow_style__hover=”none” header_4_text_shadow_style__hover_enabled=”none” header_4_text_shadow_color__hover=”rgba(0,0,0,0.4)” header_4_text_shadow_color__hover_enabled=”rgba(0,0,0,0.4)”]<\/p>\n Polynucleotides are popular due to their ability to promote tissue repair, collagen synthesis and overall skin regeneration. Benefits of Polynucleotides may include:<\/p>\n [\/et_pb_text][et_pb_text _builder_version=”4.14.2″ text_font=”||||||||” text_line_height=”2em” header_font=”||||||||” header_line_height=”0em” header_3_font=”Prata||||||||” header_3_font_size=”20px” header_3_line_height=”1.6em” custom_margin=”||||false|false” custom_padding=”||0px|||” link_option_url=”#” locked=”off” global_colors_info=”{}” text_text_color__hover=”#ff7a6b” header_3_text_color__hover=”#ff7a6b” header_4_font_size__hover=”18px” header_4_font_size__hover_enabled=”18px” header_4_letter_spacing__hover=”0px” header_4_letter_spacing__hover_enabled=”0px” header_4_line_height__hover=”1em” header_4_line_height__hover_enabled=”1em” header_4_text_shadow_style__hover=”none” header_4_text_shadow_style__hover_enabled=”none” header_4_text_shadow_color__hover=”rgba(0,0,0,0.4)” header_4_text_shadow_color__hover_enabled=”rgba(0,0,0,0.4)”]<\/p>\n \u25cf Skin Rejuvenation:<\/strong> Fibroblasts (the cells responsible for producing collagen and elastin in the skin) are stimulated, improving skin texture, firmness and elasticity, which can result in a more youthful appearance. \u25cf Moisturising and Hydration:<\/strong> The skin\u2019s ability to retain moisture is enhanced, leading to improved hydration levels and a plumper, more radiant complexion. [\/et_pb_text][\/et_pb_column][et_pb_column type=”1_2″ _builder_version=”4.14.2″ _module_preset=”default” global_colors_info=”{}”][et_pb_image src=”https:\/\/drpreema.com\/wp-content\/uploads\/2024\/04\/Polynucleotides3-before-and-after-treatment-at-Dr-Preema-London-Clinic.jpg” alt=”Before and after results showing reduced fine lines, smoother texture, and improved skin tone around the eyes following polynucleotide treatment at Dr Preema London Clinic.” title_text=”Polynucleotides3 before and after treatment at Dr Preema London Clinic” _builder_version=”4.14.2″ _module_preset=”default” custom_padding=”137px|||||” global_colors_info=”{}”][\/et_pb_image][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.14.2″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.14.2″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.14.2″ _module_preset=”default” global_colors_info=”{}”]<\/p>\n Polynucleotides can be used across the face and body to improve skin quality, elasticity, and radiance \u2014 especially in delicate or difficult-to-treat zones where traditional injectables may be unsuitable. At Dr Preema London Clinic in Mayfair, we use these regenerative skin boosters to gently rejuvenate and strengthen tissue in the following areas:<\/p>\n Under-Eye Area:<\/strong> One of the most popular indications. Polynucleotides help to smooth crepey texture, reduce dark-circle appearance, and restore firmness to the thin peri-orbital skin.<\/p>\n<\/li>\n Face:<\/strong> Improves overall tone and hydration, refining fine lines and restoring luminosity to dull or tired complexions.<\/p>\n<\/li>\n Neck and D\u00e9colletage:<\/strong> Addresses crepiness, laxity and sun damage, supporting collagen and elasticity in this fragile skin.<\/p>\n<\/li>\n Hands:<\/strong> Revitalises thinning, dehydrated skin for a more youthful texture.<\/p>\n<\/li>\n Scalp:<\/strong> Encourages a healthier scalp environment, supporting improved density and vitality.<\/p>\n<\/li>\n Body Areas:<\/strong> Can be used on knees, inner arms or abdomen to target fine lines, mild laxity and textural concerns.<\/p>\n<\/li>\n<\/ul>\n Because Polynucleotides work by stimulating natural repair at a cellular level, they are highly versatile and can be integrated into bespoke treatment plans to enhance both face and body rejuvenation. During your consultation, our clinical team will assess your skin using Aura Skin Analysis to determine the most suitable treatment areas for your individual goals.<\/p>\n [\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.14.2″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.14.2″ _module_preset=”default” global_colors_info=”{}”][et_pb_image src=”https:\/\/drpreema.com\/wp-content\/uploads\/2026\/03\/Polynucleotide-Eyes.jpg” alt=”Before and after polynucleotide eye treatment \u2013 front view showing improvement in under eye skin quality, smoother texture and refreshed appearance at Dr Preema London Clinic, Mayfair London.” title_text=”Polynucleotide Eye Treatment Before and After \u2013 Under Eye Rejuvenation | Dr Preema London Clinic Mayfair” _builder_version=”4.14.2″ _module_preset=”default” global_colors_info=”{}”][\/et_pb_image][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_3,2_3″ _builder_version=”4.14.2″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”1_3″ _builder_version=”4.14.2″ _module_preset=”default” global_colors_info=”{}”][et_pb_image src=”https:\/\/drpreema.com\/wp-content\/uploads\/2025\/04\/dr-preema-polynucleotides-london-regenerative-aesthetic-medicine.jpg.webp” alt=”Dr Preema holding polynucleotide-based regenerative medicine at her Mayfair aesthetic clinic.” title_text=”dr-preema-polynucleotides-london-regenerative-aesthetic-medicine.jpg” _builder_version=”4.14.2″ _module_preset=”default” width=”100%” module_alignment=”center” border_radii=”off|20px||20px|” global_colors_info=”{}”][\/et_pb_image][\/et_pb_column][et_pb_column type=”2_3″ _builder_version=”4.14.2″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.14.2″ text_font=”||||||||” text_line_height=”2em” header_font=”||||||||” header_line_height=”0em” header_3_font=”Prata||||||||” header_3_font_size=”20px” header_3_line_height=”1.6em” custom_margin=”-2px||||false|false” custom_margin_tablet=”40px||||false|false” custom_margin_phone=”0px||||false|false” custom_margin_last_edited=”on|phone” custom_padding=”30px|20px||20px|false|false” link_option_url=”#” border_width_all=”5px” locked=”off” global_colors_info=”{}” text_text_color__hover=”#ff7a6b” header_3_text_color__hover=”#ff7a6b” header_4_font_size__hover=”18px” header_4_font_size__hover_enabled=”18px” header_4_letter_spacing__hover=”0px” header_4_letter_spacing__hover_enabled=”0px” header_4_line_height__hover=”1em” header_4_line_height__hover_enabled=”1em” header_4_text_shadow_style__hover=”none” header_4_text_shadow_style__hover_enabled=”none” header_4_text_shadow_color__hover=”rgba(0,0,0,0.4)” header_4_text_shadow_color__hover_enabled=”rgba(0,0,0,0.4)”]<\/p>\n The Dr Preema Method is a personalised approach to treating skin concerns by intelligently layering treatments to achieve optimal, long-lasting results. Rather than applying the same solution to every patient, treatments are selected, combined and timed to support the skin at each stage \u2014 enhancing outcomes while prioritising skin health and recovery.<\/p>\n Polynucleotides may be used as a standalone treatment where skin repair, resilience and regeneration are the primary focus. Where additional support is required, they can also be layered within a bespoke treatment plan:<\/p>\n With Profhilo<\/a><\/strong> With Sylfirm X<\/a><\/strong> With Sofwave<\/a><\/strong> By layering treatments in this way \u2014 or using polynucleotides alone where appropriate \u2014 The Dr Preema Method allows treatment plans to be tailored precisely to each patient, ensuring safe, natural-looking and progressive results.<\/p>\n <\/span><\/p>\n <\/span><\/p>\n [\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.5.6″ _module_preset=”default” module_alignment=”center” custom_margin=”20px||||false|false” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.5.6″ _module_preset=”default” global_colors_info=”{}”][et_pb_divider color=”#666666″ _builder_version=”4.5.6″ _module_preset=”default” width=”30%” width_tablet=”” width_phone=”60%” width_last_edited=”on|phone” module_alignment=”center” global_colors_info=”{}”][\/et_pb_divider][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.5.6″ width=”400px” module_alignment=”center” border_width_all=”30px” border_color_all=”#000000″ border_style_all=”double” box_shadow_style=”preset5″ box_shadow_vertical=”0px” box_shadow_color=”#000000″ collapsed=”off” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.4.5″ global_colors_info=”{}”][et_pb_text _builder_version=”4.14.2″ header_font=”Prata||||||||” global_colors_info=”{}”]<\/p>\n [\/et_pb_text][et_pb_slider use_bg_overlay=”off” use_text_overlay=”off” _builder_version=”4.14.2″ header_font_size=”28px” background_color=”#000000″ border_color_all=”rgba(0,0,0,0)” border_style_all=”double” global_colors_info=”{}”][et_pb_slide heading=”Appointment Time” _builder_version=”4.5.6″ global_colors_info=”{}” sticky_transition=”on”]<\/p>\n 30 minutes<\/p>\n <\/p>\n [\/et_pb_slide][et_pb_slide heading=”Comfort Level” _builder_version=”4.14.2″ global_colors_info=”{}” sticky_transition=”on”]<\/p>\n Comfortable with numbing<\/span><\/p>\n <\/p>\n [\/et_pb_slide][et_pb_slide heading=”Action to take effect” _builder_version=”4.14.2″ global_colors_info=”{}” sticky_transition=”on”]<\/p>\n 2 weeks<\/p>\n [\/et_pb_slide][et_pb_slide heading=”Number of treatments” _builder_version=”4.14.2″ global_colors_info=”{}” sticky_transition=”on”]<\/p>\n taken 2-3 weeks apart<\/p>\n [\/et_pb_slide][et_pb_slide heading=”Duration of effect” _builder_version=”4.14.2″ global_colors_info=”{}” sticky_transition=”on”]<\/p>\n Up to 6 months<\/p>\n [\/et_pb_slide][\/et_pb_slider][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.5.6″ _module_preset=”default” module_alignment=”center” custom_margin=”20px||||false|false” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.5.6″ _module_preset=”default” global_colors_info=”{}”][et_pb_divider color=”#666666″ _builder_version=”4.5.6″ _module_preset=”default” width=”30%” width_tablet=”” width_phone=”60%” width_last_edited=”on|phone” module_alignment=”center” global_colors_info=”{}”][\/et_pb_divider][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.5.6″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.5.6″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.14.2″ header_font=”Prata||||||||” custom_margin=”16px||8px||false|false” custom_padding=”8px||0px||false|false” global_colors_info=”{}”]<\/p>\n [\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.5.6″ _module_preset=”default” width=”55%” width_tablet=”” width_phone=”90%” width_last_edited=”on|phone” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.5.6″ _module_preset=”default” global_colors_info=”{}”][et_pb_accordion _builder_version=”4.14.2″ global_colors_info=”{}”][et_pb_accordion_item title=”Closed” open=”on” _builder_version=”4.4.6″ custom_css_main_element=”display:none;” global_colors_info=”{}”][\/et_pb_accordion_item][et_pb_accordion_item title=”Click to view images” _builder_version=”4.14.2″ global_colors_info=”{}” open=”off”] [\/et_pb_text][et_pb_image src=”https:\/\/drpreema.com\/wp-content\/uploads\/2020\/05\/red-stars.png.jpg” alt=”Dr Preema London Clinic five stars review” title_text=”red stars.png” align=”center” align_tablet=”center” align_phone=”” align_last_edited=”on|desktop” _builder_version=”4.14.2″ custom_margin=”||0px” global_colors_info=”{}”][\/et_pb_image][et_pb_slider show_arrows=”off” show_image_video_mobile=”on” _builder_version=”4.14.2″ header_font=”||||||||” body_font=”||||||||” body_text_color=”rgba(0,0,0,0.6)” body_font_size=”16px” body_line_height=”2em” min_height=”243.6px” custom_margin=”||-78px|||” custom_padding=”20px||” custom_padding_tablet=”60px||” custom_padding_phone=”20px||” custom_padding_last_edited=”on|phone” auto=”on” auto_speed=”10000″ text_shadow_style=”preset1″ text_shadow_color=”rgba(0,0,0,0)” global_colors_info=”{}”][et_pb_slide _builder_version=”4.14.2″ background_color=”rgba(0,0,0,0)” background_enable_color=”on” global_colors_info=”{}” sticky_transition=”on”]<\/p>\n [\/et_pb_slide][\/et_pb_slider][\/et_pb_column][et_pb_column type=”1_5″ _builder_version=”3.25″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.14.2″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.14.2″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.14.2″ _module_preset=”default” global_colors_info=”{}”]<\/p>\n [\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.14.2″ _module_preset=”default” custom_padding=”10px||||false|false” custom_css_main_element=”padding-bottom: 0;” global_module=”57594″ saved_tabs=”all” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.14.2″ _module_preset=”default” global_colors_info=”{}”][et_pb_code module_id=”trust-reviews” _builder_version=”4.14.2″ _module_preset=”default” global_colors_info=”{}”]What are the benefits of Polynucleotides?<\/span><\/h2>\n
\u25cf Wound Healing:<\/strong> Polynucleotides may aid in the repair of damaged tissue and promote faster recovery from certain skin conditions or treatments, including Secret RF or Medical Needling.<\/p>\n
\u25cf Anti-Inflammatory:<\/strong> Reduction in redness, swelling and irritation of the skin.<\/p>\nWhat Areas Can Be Treated with Polynucleotides?<\/h2>\n
\n
The Dr Preema Method<\/h2>\n
Polynucleotides support skin repair and tissue quality, while Profhilo improves hydration and elasticity. Together, they help enhance overall skin quality, comfort and resilience, particularly in fragile or depleted skin.<\/p>\n
Polynucleotides support healing and skin recovery, while Sylfirm X stimulates collagen and improves texture. Layering these treatments can help optimise skin response and overall tone and quality.<\/p>\n
Polynucleotides help strengthen and support the skin, while Sofwave targets deeper collagen to improve firmness and laxity. This combination addresses both skin quality and structural support where needed.<\/p>\nAt a glance<\/h2>\n
3<\/strong><\/h3>\n
Before & After Polynucleotides<\/h2>\n
![\"Before](\"https:\/\/i0.wp.com\/drpreema.com\/wp-content\/uploads\/2024\/04\/Polynucleotides3-before-and-after-treatment-at-Dr-Preema-London-Clinic.jpg?fit=1024%2C1024&ssl=1\")
[\/et_pb_accordion_item][\/et_pb_accordion][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_5,3_5,1_5″ module_class=” et_pb_row_fullwidth” _builder_version=”4.5.6″ background_image=”https:\/\/drpreema.com\/wp-content\/uploads\/2020\/02\/quotes.png” background_size=”initial” background_position=”top_left” width=”89%” width_tablet=”80%” width_phone=”” width_last_edited=”on|desktop” max_width=”89%” max_width_tablet=”80%” max_width_phone=”” max_width_last_edited=”on|desktop” custom_margin=”|auto|-81px|auto||” make_fullwidth=”on” locked=”off” global_colors_info=”{}”][et_pb_column type=”1_5″ _builder_version=”3.25″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][\/et_pb_column][et_pb_column type=”3_5″ _builder_version=”3.25″ custom_padding=”60px|||” custom_padding_tablet=”0px||” custom_padding_phone=”” custom_padding_last_edited=”on|phone” global_colors_info=”{}” padding_tablet=”0px||” padding_last_edited=”on|phone” custom_padding__hover=”|||” padding_phone=”0px||”][et_pb_text _builder_version=”4.14.2″ text_font=”Open Sans||||||||” text_line_height=”2em” header_font=”||||||||” header_2_font=”Prata||||||||” header_2_font_size=”50px” header_2_line_height=”1.4em” header_3_font=”Open Sans|700||on|||||” header_3_font_size=”14px” header_3_letter_spacing=”5px” header_3_line_height=”1.8em” text_orientation=”center” max_width=”600px” module_alignment=”center” animation_style=”zoom” animation_intensity_zoom=”5%” header_2_font_size_tablet=”40px” header_2_font_size_phone=”28px” header_2_font_size_last_edited=”on|phone” header_3_font_size_tablet=”” header_3_font_size_phone=”10px” header_3_font_size_last_edited=”on|phone” locked=”off” global_colors_info=”{}” header_5_font_size__hover=”16px” header_5_font_size__hover_enabled=”16px” header_5_letter_spacing__hover=”0px” header_5_letter_spacing__hover_enabled=”0px” header_5_line_height__hover=”1em” header_5_line_height__hover_enabled=”1em” header_5_text_shadow_style__hover=”none” header_5_text_shadow_style__hover_enabled=”none” header_5_text_shadow_color__hover=”rgba(0,0,0,0.4)” header_5_text_shadow_color__hover_enabled=”rgba(0,0,0,0.4)” header_font_size__hover=”30px” header_font_size__hover_enabled=”30px” header_letter_spacing__hover=”0px” header_letter_spacing__hover_enabled=”0px” header_text_shadow_style__hover=”none” header_text_shadow_style__hover_enabled=”none” header_text_shadow_color__hover=”rgba(0,0,0,0.4)” header_text_shadow_color__hover_enabled=”rgba(0,0,0,0.4)” header_6_letter_spacing__hover=”0px” header_6_letter_spacing__hover_enabled=”0px” header_6_line_height__hover=”1em” header_6_line_height__hover_enabled=”1em” header_6_font_size__hover=”14px” header_6_font_size__hover_enabled=”14px” header_6_text_shadow_style__hover=”none” header_6_text_shadow_style__hover_enabled=”none” header_6_text_shadow_color__hover=”rgba(0,0,0,0.4)” header_6_text_shadow_color__hover_enabled=”rgba(0,0,0,0.4)” header_2_line_height__hover=”1em” header_2_2_line_height__hover=”1em” header_3_2_line_height__hover=”1em” header_4_2_line_height__hover=”1em” header_5_2_line_height__hover=”1em” header_6_2_line_height__hover=”1em” header_2_line_height__hover_enabled=”1em” header_2_2_line_height__hover_enabled=”1em” header_3_2_line_height__hover_enabled=”1em” header_4_2_line_height__hover_enabled=”1em” header_5_2_line_height__hover_enabled=”1em” header_6_2_line_height__hover_enabled=”1em”]<\/p>\nTestimonials<\/h3>\n
What They Say<\/h3>\n
Book Now<\/strong><\/span><\/h3>\n
Discover the regenerative power of Polynucleotides \u2014 book your personal consultation with Dr Preema Vig and begin your journey to naturally revitalised skin<\/a><\/h3>\n