Dr Preema Vig consulting a patient about injectable skin booster treatments at her Mayfair clinic

Polynucleotides vs Profhilo – Which Treatment Is Right for You?

Understanding the new generation of regenerative skin boosters at Dr Preema London Clinic, Mayfair

Both Polynucleotides and Profhilo® have become sought-after injectables for patients seeking smoother, firmer, more radiant skin without surgery. As technology advances, Profhilo Structura has joined the field, promising deeper support and lift. While all three deliver rejuvenation, they work in distinct ways — and choosing the right option depends on your skin’s needs.

Before and after results showing reduced fine lines, smoother texture, and improved skin tone around the eyes following polynucleotide treatment at Dr Preema London Clinic.

Polynucleotides – Regenerate and Repair at a Cellular Level

Polynucleotides are advanced biostimulators that harness purified DNA fragments to activate your skin’s natural repair processes. Once injected, they signal fibroblasts to produce fresh collagen, elastin, and hyaluronic acid, rebuilding tissue strength and resilience from within.

They also help calm inflammation and oxidative stress, making them ideal for sensitive, crepey or tired skin that needs regeneration rather than volumisation.

Think of Polynucleotides as the treatment that repairs and rejuvenates your skin’s foundation — restoring quality, not changing shape.

Profhilo treatment before and after showing reduced crepey skin and improved skin laxity on the neck.

Profhilo – Bioremodelling Through Deep Hydration

Profhilo remains one of the most recognised skin boosters worldwide. Using ultra-pure hyaluronic acid in two molecular weights, it spreads evenly beneath the skin to deeply hydrate and remodel, stimulating collagen and elastin production for firmer, more luminous skin.

It is a superb choice for patients experiencing early signs of ageing, dryness or dullness, particularly across the face, neck and décolletage.

Think of Profhilo as a treatment that replenishes moisture and suppleness — a dewy, natural refresh from within.

Before and after results showing Profhilo Structura’s subtle lifting effect by supporting the lateral fat compartments of the midface.

Profhilo Structura – Strengthen and Lift with Support

The latest evolution in the Profhilo range, Profhilo Structura is formulated for areas requiring structural reinforcement. It combines hybrid hyaluronic acids in a more viscous matrix that integrates with the subcutaneous layers, helping to restore contour and definition while still supporting collagen stimulation.

This makes it ideal for areas such as the mid-face, jawline and temples, where subtle lift and tightening are desired.

Think of Profhilo Structura as bioremodelling with gentle lift — strengthening the framework that shapes the face.

Dr Preema Vig holding injectable syringes at her Mayfair London clinic, specialists in advanced skin rejuvenation

How They Differ

Treatment	Key Action	Primary Benefit	Ideal For
Polynucleotides	Stimulate fibroblast repair	Improves texture, tone & elasticity	Crepey, fragile or inflamed skin
Profhilo	Deep HA hydration	Smooths, firms & boosts luminosity	Dehydrated or mildly lax skin
Profhilo Structura	Structural support & lift	Rebuilds contour & firmness	Mid-face or jawline laxity

If we think of the skin as a house: Polynucleotides repair the bricks and mortar, Profhilo replenishes the moisture in the walls, and Profhilo Structura reinforces the beams that hold everything in place.

Dr Preema Vig holding Profhilo injectable at her Mayfair London aesthetic clinic

Can They Be Combined?

Yes — and in expert hands, combining these treatments can deliver exceptional results. At Dr Preema London Clinic, our clinicians often design layered rejuvenation protocols, using Polynucleotides to strengthen the skin’s quality before introducing Profhilo or Profhilo Structura to enhance hydration and lift. This holistic approach supports both immediate radiance and long-term structural integrity.

Which Should You Choose?

● Choose Polynucleotides if your skin feels thin, crepey, uneven or inflamed — particularly around the eyes, mouth or neck.

● Choose Profhilo if you want deep hydration and visible glow with minimal downtime.

● Choose Profhilo Structura if you’re noticing early sagging or loss of contour around the mid-face or jawline.

● Choose a combination for a truly bespoke plan that addresses both quality and support.

Dr Preema Vig experiencing a skin analysis with the Aura system at her Mayfair clinic.

Your Bespoke Skin Plan in Mayfair

Every patient’s skin is unique. During your consultation, our team uses the Aura Skin Analysis System to assess hydration, elasticity and cellular activity before recommending a tailored rejuvenation plan.

Whether that involves Polynucleotides, Profhilo, Structura — or a combination — your treatment will be curated to achieve subtle, natural, long-lasting results.

Book Your Consultation

Experience the most advanced regenerative injectables at Dr Preema London Clinic in Mayfair — where science meets artistry for results that look beautifully effortless.

You can begin your journey in two ways:

● Chat with AI Dr Preema, our intelligent virtual assistant, for instant guidance on which treatment may best suit your skin concerns.

● Or book your in-clinic consultation to receive a fully personalised assessment and treatment plan from our expert medical team.

Whichever route you choose, your experience will be entirely bespoke — combining innovation, precision and care for naturally radiant results.