In the world of aesthetic treatments, Revitalis, Profhilo and Polynucleotides are often grouped together — yet they are frequently misunderstood or assumed to serve the same purpose. In reality, each works in a very different way, targets different layers of the skin, and is used for distinct clinical indications.
At Dr Preema London Clinic, education sits at the heart of every treatment decision. This guide clearly explains what each treatment is, how it works and what it targets — and how, when used appropriately, they can complement one another under “The Dr Preema Method”, our bespoke approach to individualised treatment planning and intelligent layering for optimal, natural results.
Profhilo: Deep Hydration & Skin Remodelling
Profhilo is a hyaluronic acid–based injectable designed to improve skin hydration, elasticity and overall skin quality, without adding volume or altering facial structure.
It contains a high concentration of stabilised hyaluronic acid, which disperses within the skin to support:
● Deep hydration
● Improved elasticity
● Collagen and elastin stimulation
● Smoother, firmer skin texture
Profhilo works primarily within the dermal layer, helping the skin remodel itself gradually and naturally over time. Variations within the Profhilo family (Profhilo Structura and Profhilo Body) apply the same principles to different anatomical areas or levels of tissue support.
Best suited for:
● Skin that feels dry, crepey or lax
● Early to moderate skin ageing
● Patients seeking improved skin quality without added volume
Revitalis: Structural Skin Support & Longevity
Revitalis is sometimes compared to Profhilo, but clinically they are designed to do different things.
While Profhilo is primarily focused on deep hydration and overall skin quality, Revitalis is formulated to support the structure and resilience of the skin over time.
Revitalis contains hyaluronic acid, but its formulation is designed to work more gradually within the skin to improve:
● Skin strength and resilience
● Tissue quality and density
● Long-term firmness and support
Rather than delivering an immediate “hydrated glow” alone, Revitalis is aimed at reinforcing the skin’s underlying framework, making it particularly suitable for patients who want to strengthen and future-proof the skin, rather than simply refresh it.
Best suited for:
● Skin that feels thin, fragile or less resilient
● Patients concerned about long-term skin ageing
● Those seeking improved firmness and structural support rather than hydration alone
Polynucleotides: Cellular Repair & Skin Regeneration
Polynucleotides are fundamentally different from both Profhilo and Revitalis.
Rather than acting primarily as a hydrator or skin supporter, Polynucleotides work at a cellular level to stimulate repair, regeneration and tissue healing. Derived from highly purified DNA fragments, they help to:
● Improve skin repair and recovery
● Enhance tissue quality
● Support collagen production
● Calm inflammation
● Improve skin texture and tone
Polynucleotides are particularly valuable in delicate or compromised areas, such as the under-eye region, neck, or skin that has been weakened by ageing, inflammation or previous treatments.
Best suited for:
● Crepey or fragile skin
● Under-eye rejuvenation
● Post-treatment recovery
● Improving skin vitality and repair
Polynucleotides do not replace Profhilo or Revitalis. Instead, they address a different biological process — skin regeneration rather than hydration or structural support.
Why They’re Often Confused — And Why They’re Not Interchangeable
The confusion arises because all three treatments:
● Are injectable
● Improve skin quality
● Do not create traditional filler volume
However, their mechanisms of action are entirely different:
● Profhilo hydrates and remodels the dermis
● Revitalis strengthens and supports skin structure
● Polynucleotides regenerate and repair at a cellular level
One does not replace the other — they simply address different skin needs.
The Dr Preema Method: Thoughtful Treatment Layering
Many patients achieve excellent results with Profhilo, Revitalis or Polynucleotides as standalone treatments — and in many cases, this is exactly the right approach.
At Dr Preema London Clinic, we also consider how results can be supported and optimised over time. The Dr Preema Method is our personalised way of planning treatments thoughtfully, selecting and timing them to work in harmony with the skin when clinically appropriate.
While Profhilo and Revitalis are not used together, either may be carefully layered with Polynucleotides to support skin quality, resilience and repair. This allows us to address hydration or structure alongside cellular regeneration, helping to create results that look natural, balanced and long-lasting.
Every treatment plan begins with a detailed medical consultation, ensuring recommendations are guided by your skin’s needs, your goals, and long-term skin health — not trends or templates.
Final Thoughts
Profhilo, Revitalis and Polynucleotides are all established, evidence-led treatments — and each is very much here to stay. One has not replaced another; instead, each continues to play a distinct role within modern aesthetic medicine when used for the right indication.
Understanding these differences allows treatments to be selected thoughtfully, rather than driven by trends. Whether used as standalone options or layered intelligently, the goal is always the same: to support skin health, resilience and natural-looking results over time.
To explore which approach is most appropriate for your skin, you can book a consultation with Dr Preema, or if you have questions before coming in, chat with Dr Preema AI for guidance and education ahead of your visit.
