Polynucleotides London

What are Polynucleotides?

Polynucleotides are the next generation of regenerative injectables, celebrated for their ability to revitalise skin from within rather than simply filling or tightening it. Often referred to as biostimulators, they contain highly purified, sterilised fish DNA fragments — most commonly derived from salmon or trout — which work at a cellular level to repair, regenerate and protect the skin.

Once injected, these DNA molecules signal fibroblast activity, stimulating the natural production of collagen, elastin and hyaluronic acid. The result is smoother, firmer, more luminous skin that looks naturally refreshed — without added volume or drastic change. Polynucleotides also have anti-inflammatory and antioxidant properties, helping to restore skin health, improve texture, and calm signs of stress or damage.

At Dr Preema London Clinic in Mayfair, Polynucleotides are used within personalised treatment plans to strengthen and renew the skin’s foundation, supporting long-term rejuvenation and overall skin vitality.

Polynucleotide injection being performed at Dr Preema London Clinic to support collagen synthesis and skin healing in men.

What are the benefits of Polynucleotides?

Polynucleotides are popular due to their ability to promote tissue repair, collagen synthesis and overall skin regeneration. Benefits of Polynucleotides may include:

● Skin Rejuvenation: Fibroblasts (the cells responsible for producing collagen and elastin in the skin) are stimulated, improving skin texture, firmness and elasticity, which can result in a more youthful appearance.
● Wound Healing: Polynucleotides may aid in the repair of damaged tissue and promote faster recovery from certain skin conditions or treatments, including Secret RF or Medical Needling.

● Moisturising and Hydration: The skin’s ability to retain moisture is enhanced, leading to improved hydration levels and a plumper, more radiant complexion.
● Anti-Inflammatory: Reduction in redness, swelling and irritation of the skin.

Before and after results showing reduced fine lines, smoother texture, and improved skin tone around the eyes following polynucleotide treatment at Dr Preema London Clinic.

What Areas Can Be Treated with Polynucleotides?

Polynucleotides can be used across the face and body to improve skin quality, elasticity, and radiance — especially in delicate or difficult-to-treat zones where traditional injectables may be unsuitable. At Dr Preema London Clinic in Mayfair, we use these regenerative skin boosters to gently rejuvenate and strengthen tissue in the following areas:

Under-Eye Area: One of the most popular indications. Polynucleotides help to smooth crepey texture, reduce dark-circle appearance, and restore firmness to the thin peri-orbital skin.
Face: Improves overall tone and hydration, refining fine lines and restoring luminosity to dull or tired complexions.
Neck and Décolletage: Addresses crepiness, laxity and sun damage, supporting collagen and elasticity in this fragile skin.
Hands: Revitalises thinning, dehydrated skin for a more youthful texture.
Scalp: Encourages a healthier scalp environment, supporting improved density and vitality.
Body Areas: Can be used on knees, inner arms or abdomen to target fine lines, mild laxity and textural concerns.

Because Polynucleotides work by stimulating natural repair at a cellular level, they are highly versatile and can be integrated into bespoke treatment plans to enhance both face and body rejuvenation. During your consultation, our clinical team will assess your skin using Aura Skin Analysis to determine the most suitable treatment areas for your individual goals.

Dr Preema holding polynucleotide-based regenerative medicine at her Mayfair aesthetic clinic.

What treatments can be combined with Polynucleotides?

Polynucleotide treatments can be combined with many other treatments, depending on your individual skin concerns. These may include Dermal Fillers for facial volume, Profhilo for skin hydration and Secret RF or Laser Genesis for skin resurfacing.

At a glance

Appointment Time

30 minutes

Comfort Level

Comfortable with numbing

Action to take effect

2 weeks

Number of treatments

3

taken 2-3 weeks apart

Duration of effect

Up to 6 months

Before & After Polynucleotides

Closed

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Testimonials

What They Say

“I found the polynucleotide treatments helped with my loose skin on my eyelids. They made a noticeable difference and these treatments will definitely be something I add to my regular skincare routine in future.”

Ruth M.